Polyamines directly promote antizyme-mediated degradation of ornithine decarboxylase by the proteasome
Ornithine decarboxylase (ODC), a ubiquitin-independent substrate of the proteasome, is a homodimeric protein with a rate-limiting function in polyamine biosynthesis. Polyamines regulate ODC levels by a feedback mechanism mediated by ODC antizyme (OAZ). Higher cellular polyamine levels trigger the sy...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shared Science Publishers OG
2015-05-01
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| Series: | Microbial Cell |
| Subjects: | |
| Online Access: | http://microbialcell.com/researcharticles/polyamines-directly-promote-antizyme-mediated-degradation-of-ornithine-decarboxylase-by-the-proteasome/ |
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