Polyamines directly promote antizyme-mediated degradation of ornithine decarboxylase by the proteasome

Polyamines directly promote antizyme-mediated degradation of ornithine decarboxylase by the proteasome

Ornithine decarboxylase (ODC), a ubiquitin-independent substrate of the proteasome, is a homodimeric protein with a rate-limiting function in polyamine biosynthesis. Polyamines regulate ODC levels by a feedback mechanism mediated by ODC antizyme (OAZ). Higher cellular polyamine levels trigger the sy...

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Bibliographic Details
Main Authors: R. Roshini Beenukumar, Daniela Gödderz, R. Palanimurugan, R. Jürgen Dohmen
Format: Article
Language:English
Published: Shared Science Publishers OG 2015-05-01
Series:Microbial Cell
Subjects:
antizyme
ODC
polyamines
proteasome
ubiquitin
Online Access:http://microbialcell.com/researcharticles/polyamines-directly-promote-antizyme-mediated-degradation-of-ornithine-decarboxylase-by-the-proteasome/
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http://microbialcell.com/researcharticles/polyamines-directly-promote-antizyme-mediated-degradation-of-ornithine-decarboxylase-by-the-proteasome/

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