Loss of FXR or Bile Acid-dependent Inhibition Accelerate Carcinogenesis of Gastroesophageal AdenocarcinomaSummary

Loss of FXR or Bile Acid-dependent Inhibition Accelerate Carcinogenesis of Gastroesophageal AdenocarcinomaSummary

Background & Aims: The incidence of Barrett esophagus (BE) and gastroesophageal adenocarcinoma (GEAC) correlates with obesity and a diet rich in fat. Bile acids (BAs) support fat digestion and undergo microbial metabolism in the gut. The farnesoid X receptor (FXR) is an important modulator o...

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Main Authors: Theresa Baumeister, Andrea Proaño-Vasco, Amira Metwaly, Karin Kleigrewe, Alexander Kuznetsov, Linus R. Schömig, Martin Borgmann, Mohammed Khiat, Akanksha Anand, Julia Strangmann, Katrin Böttcher, Dirk Haller, Andreas Dunkel, Veronika Somoza, Sinah Reiter, Chen Meng, Robert Thimme, Roland M. Schmid, Deepa T. Patil, Elke Burgermeister, Yiming Huang, Yiwei Sun, Harris H. Wang, Timothy C. Wang, Julian A. Abrams, Michael Quante
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Gastroesophageal Adenocarcinoma
Barrett Esophagus
Bile Acids
Farnesoid X Receptor
Obeticholic Acid
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X25000463
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