Novel Type I/II Carbazole/Benzindole Photosensitizers Achieve Chemo-Photodynamic Synergistic Therapy for Suppressing Solid Tumors and Drug-Resistant Bacterial Infections

Novel Type I/II Carbazole/Benzindole Photosensitizers Achieve Chemo-Photodynamic Synergistic Therapy for Suppressing Solid Tumors and Drug-Resistant Bacterial Infections

To address the clinical challenges posed by symbiotic drug-resistant bacterial infections and tumor microenvironments, this study designed and synthesized novel carbazole/benzindole-based photosensitizers <b>A1</b>–<b>A4</b>, systematically evaluating their antitumor and anti...

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Bibliographic Details
Main Authors: Zihao Wang, Xiao Liu, Yifan Ma, Jiaxin Zheng, Ke Xu, Yingxue Chang, Zhaoyan Ye, Yong Ling, Lei Wang
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Molecules
Subjects:
photodynamic therapy (PDT)
drug-resistant bacterial infection
MRSA
reactive oxygen species (ROS)
tumor microenvironment
Online Access:https://www.mdpi.com/1420-3049/30/12/2560
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