Transglutaminase 2 contributes to apoptosis induction in Jurkat T cells by modulating Ca2+ homeostasis via cross-linking RAP1GDS1.

<h4>Background</h4>Transglutaminase 2 (TG2) is a protein cross-linking enzyme known to be associated with the in vivo apoptosis program of T cells. However, its role in the T cell apoptosis program was not investigated yet.<h4>Results</h4>Here we report that timed overexpress...

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Main Authors: Yu-Fan Hsieh, Guang-Yaw Liu, Yi-Ju Lee, Jiann-Jou Yang, Katalin Sándor, Zsolt Sarang, Angela Bononi, Paolo Pinton, László Tretter, Zsuzsa Szondy, Gregory J Tsay
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0081516
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