Tanshinone IIA suppresses fibro-adipogenic progenitor differentiation and attenuates fat infiltration in rotator cuff injury via Wnt/β-catenin pathway

Tanshinone IIA suppresses fibro-adipogenic progenitor differentiation and attenuates fat infiltration in rotator cuff injury via Wnt/β-catenin pathway

Background: Fibro-adipogenic progenitors (FAPs) contribute to excessive muscular fatty infiltration after rotator cuff tears (RCT), impairing shoulder function. Tanshinone IIA (Tan IIA), a major active compound from Salvia miltiorrhiza Bunge, has known anti-adipogenic effects, yet its impact on FAP...

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Bibliographic Details
Main Authors: Yumei Zhang, Xinghua Li, Rui Zhang, Minhui Wang, Tihui Wang, Guanfeng Liu, Amila Kuati, Wenhua Mao
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:Regenerative Therapy
Subjects:
Rotator cuff tears
Fibro-adipogenic progenitors
Adipogenesis
Tanshinone IIA
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320425001725
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