Preconditioning of microglia by α-synuclein strongly affects the response induced by toll-like receptor (TLR) stimulation.

Preconditioning of microglia by α-synuclein strongly affects the response induced by toll-like receptor (TLR) stimulation.

In recent years, it has become accepted that α-synuclein (αSyn) has a key role in the microglia-mediated neuroinflammation, which accompanies the development of Parkinson's disease and other related disorders, such as Dementia with Lewy Bodies and Alzheimer's disease. Nevertheless, the cel...

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Main Authors: Cintia Roodveldt, Adahir Labrador-Garrido, Elena Gonzalez-Rey, Christian C Lachaud, Tim Guilliams, Rafael Fernandez-Montesinos, Alicia Benitez-Rondan, Gema Robledo, Abdelkrim Hmadcha, Mario Delgado, Christopher M Dobson, David Pozo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0079160
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https://doi.org/10.1371/journal.pone.0079160

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