Discovery and validation of cell-free DNA methylation markers for specific diagnosis, differentiation from benign tumors, and prognosis of breast cancer

Discovery and validation of cell-free DNA methylation markers for specific diagnosis, differentiation from benign tumors, and prognosis of breast cancer

Abstract Background Plasma cell-free DNA (cfDNA) methylation is emerging as a non-invasive marker for various cancers. We aimed to identify specific methylation markers for diagnosis, differentiation from benign tumors, and prognosis of breast cancer (BC), which are essential for clinical decision-m...

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Main Authors: Lijing Gao, Lei Zhang, Jinyin Liu, Liwan Wang, Qingzhen Fu, Siyu Liu, Yanbing Li, Chao Qu, Ning Zhao, Shiheng Tan, Fang Fang, Tian Tian, Shi Jiang, Junxiao Wu, Yan Dong, Yajie Gong, Yukun Cao, Fan Wang, Xianyu Zhang, Da Pang, Yashuang Zhao
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Cell-free DNA
Methylation
Multiplex droplet digital PCR
Diagnosis
Prognosis
Online Access:https://doi.org/10.1186/s13058-025-02066-x
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https://doi.org/10.1186/s13058-025-02066-x

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