Design and evaluation of novel triazole derivatives as potential anti-gout inhibitors: a comprehensive molecular modeling study

Design and evaluation of novel triazole derivatives as potential anti-gout inhibitors: a comprehensive molecular modeling study

IntroductionGout is the most common inflammatory arthritis, characterized by hyperuricemia, tophus formation, joint disease, and kidney stones. Uric acid, the final byproduct of purine catabolism, is eliminated via the kidneys and digestive system. Xanthine oxidase (XO) catalyzes the conversion of h...

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Main Authors: Mohammed Er-rajy, Mohamed El fadili, Sara Zarougui, Somdutt Mujwar, Mourad Aloui, Mohammed Zerrouk, Belkheir Hammouti, Larbi Rhazi, Rachid Sabbahi, Mohammed M. Alanazi, Khalil Azzaoui, Rachid Salghi, Menana Elhallaoui
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Chemistry
Subjects:
3D-QSAR
anti-gout drugs
molecular docking
molecular dynamic
conception of novel derivatives
ADMET proprieties
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2025.1518777/full
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https://www.frontiersin.org/articles/10.3389/fchem.2025.1518777/full

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