Multiomics reveals metformin’s dual role in gut microbiome remodeling and hepatic metabolic reprogramming for MAFLD intervention

Multiomics reveals metformin’s dual role in gut microbiome remodeling and hepatic metabolic reprogramming for MAFLD intervention

Abstract Metabolic Associated Fatty Liver Disease (MAFLD), previously known as Non-Alcoholic Fatty Liver Disease, is a growing global health issue associated with obesity, type 2 diabetes, and metabolic syndrome. This study investigates the potential of metformin, a common anti-diabetic drug, to slo...

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Bibliographic Details
Main Authors: Yuan-dong Sun, Hao Zhang, Xiao-long Gong, Yuan-min Li, Ruiqin Han, Chun-xiao Zhou, Jian-jun Han
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Metabolic associated fatty liver disease
Liver cirrhosis
Metformin
Multi-omics
Liver metabolism
Online Access:https://doi.org/10.1038/s41598-025-07557-7
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https://doi.org/10.1038/s41598-025-07557-7

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