Temporally integrated single cell RNA sequencing analysis of PBMC from experimental and natural primary human DENV-1 infections.

Temporally integrated single cell RNA sequencing analysis of PBMC from experimental and natural primary human DENV-1 infections.

Dengue human infection studies present an opportunity to address many longstanding questions in the field of flavivirus biology. However, limited data are available on how the immunological and transcriptional response elicited by an attenuated challenge virus compares to that associated with a wild...

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Main Authors: Adam T Waickman, Heather Friberg, Gregory D Gromowski, Wiriya Rutvisuttinunt, Tao Li, Hayden Siegfried, Kaitlin Victor, Michael K McCracken, Stefan Fernandez, Anon Srikiatkhachorn, Damon Ellison, Richard G Jarman, Stephen J Thomas, Alan L Rothman, Timothy Endy, Jeffrey R Currier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009240&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009240&type=printable

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