Loss of vitamin D receptor induces premature ovarian insufficiency through compromising the 7-dehydrocholesterol-dependent anti-aging effects

Loss of vitamin D receptor induces premature ovarian insufficiency through compromising the 7-dehydrocholesterol-dependent anti-aging effects

Vitamin D has the potential to therapeutically affect the endocrine parameters of premature ovarian insufficiency (POI) patients. Previous research has indicated that serum vitamin D levels tend to decline with age and in individuals with POI. However, the precise impact of vitamin D deficiency on f...

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Bibliographic Details
Main Authors: Haiyun Chen, Qiuyi Wang, Yi Zhang, Luxi Shangguan, Zhengquan Zhu, Huan Zhang, Xiang Zou, Qinghe Geng, Yanting Wen, Daojuan Wang, Yong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
VDR
premature ovarian insufficiency (POI)
granulosa cell
7-dehydrocholesterol (7-DHC)
aging
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1545167/full
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https://www.frontiersin.org/articles/10.3389/fcell.2025.1545167/full

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