Transactivation of the EGF receptor as a novel desensitization mechanism for G protein-coupled receptors, illustrated by dopamine D2-like and β2 adrenergic receptors

Transactivation of the EGF receptor as a novel desensitization mechanism for G protein-coupled receptors, illustrated by dopamine D2-like and β2 adrenergic receptors

Abstract Transactivation of epidermal growth factor receptors (EGFR) provides intricate control over multiple regulatory cellular processes that merge the diversity of G protein-coupled receptors (GPCRs) with the robust signaling capacities of receptor tyrosine kinases. Contrary to the typical asser...

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Bibliographic Details
Main Authors: Dooti Kundu, Xiao Min, Shujie Wang, Lulu Peng, Xinru Tian, Mengling Wang, Kyeong-Man Kim
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Cellular & Molecular Biology Letters
Subjects:
GPCR
EGFR
Transactivation
Desensitization
Arrestin
Deubiquitination
Online Access:https://doi.org/10.1186/s11658-024-00652-z
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https://doi.org/10.1186/s11658-024-00652-z

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