The emerging role of next-generation sequencing in minimal residual disease assessment in acute lymphoblastic leukemia: a systematic review of current literature

The emerging role of next-generation sequencing in minimal residual disease assessment in acute lymphoblastic leukemia: a systematic review of current literature

BackgroundMinimal residual disease (MRD) is a critical prognostic marker in acute lymphoblastic leukemia (ALL). The well studied and used MRD detection methods, multiparametric flow cytometry (MFC) and real-time quantitative polymerase chain reaction (qRT-PCR) for fusion genes and receptor gene rear...

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Bibliographic Details
Main Authors: Andreea-Iulia Ștefan, Letiția-Elena Radu, Dumitru Jardan, Anca Coliță
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Medicine
Subjects:
acute lymphoblastic leukemia
minimal residual disease
next-generation sequencing
risk stratification
event-free survival
relapse prediction
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1570041/full
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https://www.frontiersin.org/articles/10.3389/fmed.2025.1570041/full

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