Overexpression in Plasmodium falciparum of an intrinsically disordered protein segment of PfUT impairs the parasite’s proteostasis and reduces its growth rate

Overexpression in Plasmodium falciparum of an intrinsically disordered protein segment of PfUT impairs the parasite’s proteostasis and reduces its growth rate

The proteome of Plasmodium falciparum exhibits a marked propensity for aggregation. This characteristic results from the parasite’s AT-rich genome, which encodes numerous proteins with long asparagine-rich stretches and low structural complexity, which lead to abundant intrinsically disordered regio...

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Bibliographic Details
Main Authors: Yunuen Avalos-Padilla, Inés Bouzón-Arnáiz, Miriam Ramírez, Claudia Camarero-Hoyos, Marc Orozco-Quer, Elsa M. Arce, Diego Muñoz-Torrero, Xavier Fernàndez-Busquets
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Plasmodium falciparum
E3 ubiquitin ligases
proteostasis disruption
protein aggregation
new antimalarial therapies
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1565814/full
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https://www.frontiersin.org/articles/10.3389/fcimb.2025.1565814/full

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