Callus organoids reveal distinct cartilage to bone transition mechanisms across donors and a role for biological sex

Abstract Clinical translation of tissue-engineered advanced therapeutic medicinal products is hindered by a lack of patient-dependent and independent in-process biological quality controls that are reflective of in vivo outcomes. Recent insights into the mechanism of native bone repair highlight a r...

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Bibliographic Details
Main Authors: Isaak Decoene, Hanna Svitina, Mohamed Belal Hamed, Anastassios Economou, Steve Stegen, Frank P. Luyten, Ioannis Papantoniou
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-025-00418-z
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