Alpha-1 antitrypsin reduces inflammation and vasculopathy in mice with oxygen-induced retinopathy

Alpha-1 antitrypsin reduces inflammation and vasculopathy in mice with oxygen-induced retinopathy

Abstract Background Damage to the retinal vasculature is a major cause of vision loss and is influenced by a pro-inflammatory environment within retinal tissue. Alpha-1 antitrypsin (AAT) is a potent inhibitor of serine proteases and has anti-inflammatory properties. We hypothesised that AAT could re...

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Bibliographic Details
Main Authors: Varaporn Suphapimol, Yu-Han Liu, Sandro Prato, Alexander Karnowski, Charles Hardy, Adriana Baz Morelli, Abhirup Jayasimhan, Devy Deliyanti, Jennifer L. Wilkinson-Berka
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Inflammation
Subjects:
Alpha-1 antitrypsin
Oxygen-induced retinopathy
Inflammation
Microglia
Neovascularisation
Vascular leakage
Online Access:https://doi.org/10.1186/s12950-025-00431-3
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https://doi.org/10.1186/s12950-025-00431-3

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