Serum metabolomics indicates ferroptosis in patients with pantothenate kinase associated neurodegeneration

Abstract The core syndrome among NBIA disorders is pantothenate kinase-associated neurodegeneration (PKAN), an autosomal recessive disorder caused by mutations in the PANK2 gene. There is no therapy for PKAN; only symptomatic treatment is available. Our work aimed to identify the mechanisms induced...

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Bibliographic Details
Main Authors: Beata Toczylowska, Marta Skowronska, Iwona Kurkowska-Jastrzebska, Anna Ruszczynska, Elzbieta Zieminska
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-94838-w
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