ESRP1 exerts anti-tumor role by promoting ferroptosis in diffuse-type gastric cancer

ESRP1 exerts anti-tumor role by promoting ferroptosis in diffuse-type gastric cancer

Abstract Diffuse-type gastric cancer (DGC) accounts for approximately one-third of gastric cancer cases, but it is clinically more aggressive and associated with poorer survival prognosis compared to intestinal-type gastric cancer (IGC). Our study revealed significantly reduced ESRP1 expression in D...

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Bibliographic Details
Main Authors: Kang Xu, Hao Chen, Xingyu Zhu, Han Li, Xinyu Liu, Yaodong Sang, Xiaohan Wang, Xiaoling Cui, Baoshan Cai, Liang Shang, Wei Chong, Leping Li
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Epithelial splicing regulatory protein 1
Ferroptosis
Diffuse-type gastric cancer
Tumor mutational burden
Metabolism
Therapeutic target
Online Access:https://doi.org/10.1186/s13046-025-03435-2
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https://doi.org/10.1186/s13046-025-03435-2

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