The baseline circulating immunophenotype characteristics associate with PD(L)-1 targeted treatment response, irae onset, and prognosis

The baseline circulating immunophenotype characteristics associate with PD(L)-1 targeted treatment response, irae onset, and prognosis

Abstract More promising, effective, and less-invasive biomarkers for PD(L)-1 targeted responses, immune-related adverse events (irAEs), and prognosis are being explored. We conducted a single-center retrospective study in pan-cancer patients with anti-PD(L)-1 monotherapy. Observational endpoints inc...

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Main Authors: Xiaomin Fu, Fanghui Li, Hongqin You, Benling Xu, Tingjie Wang, Peng Qin, Lu Han, Yong Zhang, Fang Zhang, Lingdi Zhao, Baozhen Ma, Yiman Shang, Yonghao Yang, Zibing Wang, Jinrong Qu, Quanli Gao
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
PD(L)-1 inhibitor
Monotherapy
Response
IrAE
Prognosis
Biomarker
Online Access:https://doi.org/10.1038/s41598-025-02597-5
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https://doi.org/10.1038/s41598-025-02597-5

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