Memory CD4+ T cells sequentially restructure their 3D genome during stepwise activation

Memory CD4+ T cells sequentially restructure their 3D genome during stepwise activation

BackgroundCD4+ T cells are a highly differentiated cell type that maintain enough transcriptomic plasticity to cycle between activated and memory statuses. How the 1D chromatin state and 3D chromatin architecture support this plasticity is under intensive investigation.MethodsHere, we wished to test...

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Bibliographic Details
Main Authors: Alexander I. Ward, Jose I. de las Heras, Eric C. Schirmer, Ariberto Fassati
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
3D-genome organization
memory CD4+ T cells
sequential immune activation
gene expression regulation
Hi-C
IL-2
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1514627/full
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https://www.frontiersin.org/articles/10.3389/fcell.2025.1514627/full

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