Comprehensive analysis of PIK3CA mutations in advanced colorectal cancer using circulating tumor DNA profiling

Abstract Mutations in PIK3CA are prevalent in advanced colorectal cancer (CRC) and are associated with advanced-stage disease and poor prognosis. However, the prognostic value of these mutations remains unclear. To better understand their role in CRC progression, we evaluated the genomic landscape o...

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Bibliographic Details
Main Authors: Allante Milsap, Jill Tsai, Baqir Jafry, Alex Kim, Syed Mohammad Ali Kazmi, Nilesh Verma
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-00975-w
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