MDSC: a new potential breakthrough in CAR-T therapy for solid tumors

Abstract Chimeric antigen receptor T (CAR-T) cell therapy has shown remarkable success in hematologic malignancies but has encountered challenges in effectively treating solid tumors. One major obstacle is the presence of the immunosuppressive tumor microenvironment (TME), which is mainly built by m...

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Bibliographic Details
Main Authors: Nada Mohamady Farouk Abdalsalam, Abdulrahman Ibrahim, Muhammad Auwal Saliu, Tzu-Ming Liu, Xiaochun Wan, Dehong Yan
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cell Communication and Signaling
Subjects:
Online Access:https://doi.org/10.1186/s12964-024-01995-y
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