Active Cryptococcus neoformans glucuronoxylomannan production prevents elimination of cryptococcal CNS infection in vivo

Active Cryptococcus neoformans glucuronoxylomannan production prevents elimination of cryptococcal CNS infection in vivo

Abstract Background Cryptococcus neoformans (Cn) causes life-threatening meningoencephalitis in individuals with AIDS. Cn’s polysaccharide capsule is mainly composed of glucuronoxylomannan (GXM) and plays a key role in the dysregulation of immunity, resistance to antifungal drugs, and systemic disse...

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Main Authors: Vanessa Enriquez, Melissa E. Munzen, Luz M. Porras, Claudia L. Charles-Niño, Fahong Yu, Karina Alviña, Raddy L. Ramos, Michael R. Dores, Paola Giusti-Rodriguez, Luis R. Martinez
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Neuroinflammation
Subjects:
C. neoformans
Cryptococcoma
Meningoencephalitis
Microglia
Phagocytosis
Online Access:https://doi.org/10.1186/s12974-025-03384-9
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https://doi.org/10.1186/s12974-025-03384-9

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