cJun-N-terminal kinase activity and mitosis perturbation drive the 2-methoxyestradiol-mediated enhancement of viral oncolysis by Epizootic Hemorrhagic Disease Virus-Tel Aviv University

cJun-N-terminal kinase activity and mitosis perturbation drive the 2-methoxyestradiol-mediated enhancement of viral oncolysis by Epizootic Hemorrhagic Disease Virus-Tel Aviv University

Abstract Oncolytic viruses (OVs) are promising cancer therapies whose efficacy is restricted by tumor heterogeneity and monotherapy limitations. We investigated combining the oncolytic orbivirus Epizootic Hemorrhagic Disease Virus -Tel Aviv University (EHDV-TAU) with the microtubule-targeting agent...

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Bibliographic Details
Main Authors: Sucheta De, Shlomi Kashkash, Vladimir Bozhdansky, Eran Bacharach, Marcelo Ehrlich
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
EHDV2-TAU
2-Methoxyestradiol
JNK
Oncolytic virus
Bladder cancer
Online Access:https://doi.org/10.1038/s41598-025-08687-8
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https://doi.org/10.1038/s41598-025-08687-8

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