Haploinsufficiency of PDE2A causes in mice increased exploratory behavior associated with upregulation of neural nitric oxide synthase in the striatum

Haploinsufficiency of PDE2A causes in mice increased exploratory behavior associated with upregulation of neural nitric oxide synthase in the striatum

Phosphodiesterase 2 A (PDE2A) function is stimulated by cGMP to catabolize cAMP. However, neurological and neurochemical effects of PDE2A deficiency are poorly understood. To address this gap, we studied behavioral characteristics and cerebral morpho-chemical changes of adult male heterozygous C57BL...

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Main Authors: Ana Gabriela de Oliveira do Rêgo, Francesca D'Amico, Vincenza D’Angelo, Silvia Cardarelli, Debora Cutuli, Davide Decandia, Eugenia Landolfo, Laura Petrosini, Manuela Pellegrini, Marcello D’Amelio, Nicola Biagio Mercuri, Mauro Giorgi, Giuseppe Sancesario
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Neurobiology of Disease
Subjects:
Phosphodiesterase 2A
PDE2A heterozygous +/− mice
cAMP
cGMP
PDE3
PDE5
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124003838
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http://www.sciencedirect.com/science/article/pii/S0969996124003838

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