Insulin/IGF-I and Related Signaling Pathways Regulate Aging in Nondividing Cells: from Yeast to the Mammalian Brain
Mutations that reduce glucose or insulin/insulin-like growth factor-I (IGF-I) signaling increase longevity in organisms ranging from yeast to mammals. Over the past 10 years, several studies confirmed this conserved molecular strategy of longevity regulation, and many more have been added to the com...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2010.8 |
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| author | Edoardo Parrella Valter D. Longo |
| author_facet | Edoardo Parrella Valter D. Longo |
| author_sort | Edoardo Parrella |
| collection | DOAJ |
| description | Mutations that reduce glucose or insulin/insulin-like growth factor-I (IGF-I) signaling increase longevity in organisms ranging from yeast to mammals. Over the past 10 years, several studies confirmed this conserved molecular strategy of longevity regulation, and many more have been added to the complex mosaic that links stress resistance and aging. In this review, we will analyze the similarities that have emerged over the last decade between longevity regulatory pathways in organisms ranging from yeast, nematodes, and fruit flies to mice. We will focus on the role of yeast signal transduction proteins Ras, Tor, Sch9, Sir2, their homologs in higher organisms, and their association to oxidative stress and protective systems. We will discuss how the “molecular strategy” responsible for life span extension in response to dietary and genetic manipulations appears to be remarkably conserved in various organisms and cells, including neuronal cells in different organisms. Taken together, these studies indicate that simple model systems will contribute to our comprehension of aging of the mammalian nervous system and will stimulate novel neurotherapeutic strategies in humans. |
| format | Article |
| id | doaj-art-c7936eb0157b44adb827e1ad056a49c7 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-c7936eb0157b44adb827e1ad056a49c72025-02-03T05:52:17ZengWileyThe Scientific World Journal1537-744X2010-01-011016117710.1100/tsw.2010.8Insulin/IGF-I and Related Signaling Pathways Regulate Aging in Nondividing Cells: from Yeast to the Mammalian BrainEdoardo Parrella0Valter D. Longo1Division of Neurogerontology, Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA, USADivision of Neurogerontology, Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA, USAMutations that reduce glucose or insulin/insulin-like growth factor-I (IGF-I) signaling increase longevity in organisms ranging from yeast to mammals. Over the past 10 years, several studies confirmed this conserved molecular strategy of longevity regulation, and many more have been added to the complex mosaic that links stress resistance and aging. In this review, we will analyze the similarities that have emerged over the last decade between longevity regulatory pathways in organisms ranging from yeast, nematodes, and fruit flies to mice. We will focus on the role of yeast signal transduction proteins Ras, Tor, Sch9, Sir2, their homologs in higher organisms, and their association to oxidative stress and protective systems. We will discuss how the “molecular strategy” responsible for life span extension in response to dietary and genetic manipulations appears to be remarkably conserved in various organisms and cells, including neuronal cells in different organisms. Taken together, these studies indicate that simple model systems will contribute to our comprehension of aging of the mammalian nervous system and will stimulate novel neurotherapeutic strategies in humans.http://dx.doi.org/10.1100/tsw.2010.8 |
| spellingShingle | Edoardo Parrella Valter D. Longo Insulin/IGF-I and Related Signaling Pathways Regulate Aging in Nondividing Cells: from Yeast to the Mammalian Brain The Scientific World Journal |
| title | Insulin/IGF-I and Related Signaling Pathways Regulate Aging in Nondividing Cells: from Yeast to the Mammalian Brain |
| title_full | Insulin/IGF-I and Related Signaling Pathways Regulate Aging in Nondividing Cells: from Yeast to the Mammalian Brain |
| title_fullStr | Insulin/IGF-I and Related Signaling Pathways Regulate Aging in Nondividing Cells: from Yeast to the Mammalian Brain |
| title_full_unstemmed | Insulin/IGF-I and Related Signaling Pathways Regulate Aging in Nondividing Cells: from Yeast to the Mammalian Brain |
| title_short | Insulin/IGF-I and Related Signaling Pathways Regulate Aging in Nondividing Cells: from Yeast to the Mammalian Brain |
| title_sort | insulin igf i and related signaling pathways regulate aging in nondividing cells from yeast to the mammalian brain |
| url | http://dx.doi.org/10.1100/tsw.2010.8 |
| work_keys_str_mv | AT edoardoparrella insulinigfiandrelatedsignalingpathwaysregulateaginginnondividingcellsfromyeasttothemammalianbrain AT valterdlongo insulinigfiandrelatedsignalingpathwaysregulateaginginnondividingcellsfromyeasttothemammalianbrain |