Longitudinal characterization reveals behavioral impairments in aged APP knock in mouse models

Longitudinal characterization reveals behavioral impairments in aged APP knock in mouse models

Abstract APP knock-in (KI) mice serve as an exciting new model system to understand amyloid beta (Aβ) pathology, overcoming many of the limitations of previous overexpression-based model systems. The APPSAA mouse model (containing the humanized APP with three familial Alzheimer’s disease mutations)...

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Bibliographic Details
Main Authors: Lisa Blackmer-Raynolds, Lyndsey D. Lipson, Isabel Fraccaroli, Ian N. Krout, Jianjun Chang, Timothy Robert Sampson
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Alzheimer’s disease
Cognitive behavior
Amyloid precursor protein
Animal models
Online Access:https://doi.org/10.1038/s41598-025-89051-8
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https://doi.org/10.1038/s41598-025-89051-8

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