Feedback between p21 and reactive oxygen production is necessary for cell senescence

Feedback between p21 and reactive oxygen production is necessary for cell senescence

Abstract Cellular senescence—the permanent arrest of cycling in normally proliferating cells such as fibroblasts—contributes both to age‐related loss of mammalian tissue homeostasis and acts as a tumour suppressor mechanism. The pathways leading to establishment of senescence are proving to be more...

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Main Authors: João F Passos, Glyn Nelson, Chunfang Wang, Torsten Richter, Cedric Simillion, Carole J Proctor, Satomi Miwa, Sharon Olijslagers, Jennifer Hallinan, Anil Wipat, Gabriele Saretzki, Karl Lenhard Rudolph, Tom B L Kirkwood, Thomas von Zglinicki
Format: Article
Language:English
Published: Springer Nature 2010-02-01
Series:Molecular Systems Biology
Subjects:
aging
cell senescence
DNA damage foci
mitochondria
reactive oxygen
Online Access:https://doi.org/10.1038/msb.2010.5
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https://doi.org/10.1038/msb.2010.5

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