Venetoclax synergizes with Wnt/β-catenin inhibitor C-82 in acute myeloid leukemia by increasing the degradation of Mcl-1 protein

Venetoclax synergizes with Wnt/β-catenin inhibitor C-82 in acute myeloid leukemia by increasing the degradation of Mcl-1 protein

Abstract Background Due to compensatory survival signalling and overexpression of anti-apoptotic Bcl-2 family proteins, the majority of AML patients developed acquired resistance of venetoclax (VEN) to combination therapy of VEN with low-dose cytarabine (LDAC) or hypomethylating agents (HMAs). Dysre...

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Bibliographic Details
Main Authors: Mengya Pan, Changqing Jiao, Menghua Sun, Duo Jin, Yin Wang, Haoxuan Wu, Yan Zhang, Enbo Chen, Bobin Su, Junjie Zhou, Xiaoying Liu, Jian Ge
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cancer Cell International
Subjects:
Acute myeloid leukemia
Venetoclax
Drug resistance
Wnt/β-catenin
Mcl-1
Online Access:https://doi.org/10.1186/s12935-025-03825-8
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https://doi.org/10.1186/s12935-025-03825-8

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