Drug resistant variants of hepatitis C virus genotype 1b in Russia: analysis of aminoacid substitutions in NS5a and core proteins

Drug resistant variants of hepatitis C virus genotype 1b in Russia: analysis of aminoacid substitutions in NS5a and core proteins

Aim. To determine the prevalence of amino acid substitutions in hepatitis C virus NS5a and core proteins which are associated with resistance to direct-acting antivirals and interferon in genotype 1b (HCV-1b) strains circulating in Russia. Materials and methods. Nucleotide sequences of NS5a (n=93) a...

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Bibliographic Details
Main Authors: V. S. Kichatova, A. A. Karlsen, O. V. Isaeva, S. A. Solonin, E. Yu. Malinnikova, K. K. Kyuregyan, M. I. Mikhailov
Format: Article
Language:Russian
Published: Journal Infectology 2018-12-01
Series:Журнал инфектологии
Subjects:
hepatitis c virus (hcv)
drug resistance
ras
genetic polymorphism
Online Access:https://journal.niidi.ru/jofin/article/view/800
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