Itaconate suppresses neonatal intestinal inflammation via metabolic reprogramming of M1 macrophage

Itaconate suppresses neonatal intestinal inflammation via metabolic reprogramming of M1 macrophage

Abstract Background Necrotizing enterocolitis (NEC) is a rapidly progressive and severe gastrointestinal disorder in neonates that is marked by an inflammatory cascade initiated by mechanisms that remain incompletely understood, resulting in intestinal necrosis and systemic infections. This study de...

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Main Authors: Shuchen Huangfu, Chaoting Lan, Sitao Li, Huijuan Wang, Chun Yan, Yuling Yang, Bowen Tian, Yide Mu, Peizhi Zhao, Yan Tian, Yijia Wang, Wei Zhong, Limei Zhong, Yongyan Shi, Yufeng Liu
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Clinical and Translational Medicine
Subjects:
itaconate
macrophage
metabolic reprogramming
necrotizing enterocolitis
oxidative phosphorylation
Online Access:https://doi.org/10.1002/ctm2.70419
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https://doi.org/10.1002/ctm2.70419

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