Innovative Lipid Nanoparticles Co-Delivering Hydroxychloroquine and siRNA for Enhanced Rheumatoid Arthritis Therapy

Innovative Lipid Nanoparticles Co-Delivering Hydroxychloroquine and siRNA for Enhanced Rheumatoid Arthritis Therapy

<b>Background:</b> Rheumatoid arthritis (RA) is a debilitating autoimmune disorder characterized by chronic inflammation and joint damage. Despite advancements in treatment, complete remission remains elusive. <b>Methods:</b> In this study, we introduce a novel lipid nanopart...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yanru Feng, Xintong Pan, Ziqian Li, Yue Li, Ya’nan Sun, Shaokun Yang, Chaoxing He, Yunjie Dang, Lu Huang, Bai Xiang
Format:	Article
Language:	English
Published:	MDPI AG 2025-01-01
Series:	Pharmaceutics
Subjects:	lipid nanoparticle co-delivery hydroxychloroquine si<i>TNF-α</i> rheumatoid arthritis
Online Access:	https://www.mdpi.com/1999-4923/17/1/45
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Evaluation of the role of hydroxychloroquine as a lipid profile improving and glucose adjusting drug in Egyptian females with inactive rheumatoid arthritis
by: Aliaa O. El-Hady, et al.
Published: (2023-12-01)

Improving dexamethasone drug loading and efficacy in treating rheumatoid arthritis via liposome: Focusing on inflammation and molecular mechanisms
by: Mohammad Yasin Zamanian, et al.
Published: (2025-01-01)

siRNA therapeutics for effective management of rheumatoid arthritis
by: Vishakha R. Chakole, et al.
Published: (2025-01-01)

Identification and validation of hub gene TNFAIP6 of fibroblast-like synoviocytes in rheumatoid arthritis
by: LEI Lei, et al.
Published: (2025-02-01)

Candidate antirheumatic genotherapeutic plasmid constructions have low immunogenicity
by: T. S. Nepomnyashchikh, et al.
Published: (2017-05-01)

Liposomal Formulation of Hydroxychloroquine Can Inhibit Autophagy In Vivo
by: Wieslawa H. Dragowska, et al.
Published: (2024-12-01)

Perpetuation of inflammation associated with experimental arthritis: the role of macrophage activation by neutrophilic myeloperoxidase
by: Monique P. Gelderman, et al.
Published: (1998-01-01)

<i>Vismia guianensis</i> Improves Survival of <i>Tenebrio molitor</i> and Mice During Lethal Infection with <i>Candida albicans</i>
by: Arthur André Castro Costa, et al.
Published: (2025-01-01)

Early detection of the retinal bioelectrical dysfunction in patients treated by chloroquine/hydroxychloroquine
by: Wojciech Lubiński, et al.
Published: (2024-12-01)

Blocking TNF-α Reduces <i>Leishmania major</i>-Induced Hyperalgesia and Changes the Cytokine Profile in the Paw Skin of BALB/c Mice with a Potential Positive Effect on Parasite Clearance
by: Muriel Tahtouh Zaatar, et al.
Published: (2024-12-01)

A study of serum YKL-40 and its correlation with traditional biomarkers in rheumatoid arthritis patients
by: Vinod Narayan, et al.
Published: (2019-01-01)

Physiologically-based pharmacokinetic modeling of enantioselective hydroxychloroquine kinetics and impact of genetic polymorphisms
by: Gabriella de Souza Gomes Ribeiro, et al.
Published: (2025-01-01)

Ultrasonography of articular and periarticular structures as a relapse predictor in patients with clinically remitted rheumatoid arthritis
by: Mehdi Karami, et al.
Published: (2020-01-01)

CX3CR1+ age-associated CD4+ T cells contribute to synovial inflammation in late-onset rheumatoid arthritis
by: Mitsuhiro Akiyama, et al.
Published: (2025-02-01)

Beliefs and outlook toward medications in Indian patients with very early rheumatoid arthritis: Cross sectional survey
by: Sakir Ahmed, et al.
Published: (2020-01-01)

Risk factors of thyroid dysfunction in patients with rheumatoid arthritis
by: Lan Li, et al.
Published: (2024-06-01)

Targeting the serum marker interleukin 9 improves the underlying characterization and immune homeostasis in rheumatoid arthritis
by: Ying Xiong, et al.
Published: (2024-08-01)

Anti-arthritic potential of crude sulfated polysaccharide from marine macroalgae Sargassum ilicifolium (Turner) C. Agardh: Regulation of cytokine cascade
by: Ramamoorthi Lavanya, et al.
Published: (2025-01-01)

Association of ERAP1 and ERAP2 gene polymorphisms and ERAP2 protein with the susceptibility and severity of rheumatoid arthritis in the Ukrainian population
by: Iryna Kril, et al.
Published: (2025-01-01)

Pulmonary Nodules After Leflunomide Therapy in Rheumatoid Arthritis: A Case Report
by: Mahdiye Abiyarghamsari, et al.
Published: (2025-01-01)

Tetracyclines in Rheumatoid Arthritis: Dual Anti-Inflammatory and Immunomodulatory Roles, Effectiveness, and Safety Insights
by: Mislav Radić, et al.
Published: (2025-01-01)

Incidence of Malignancies and the Association with Biological Disease-Modifying Antirheumatic Drugs in Japanese Patients with Rheumatoid Arthritis: A Time-Dependent Analysis from the IORRA Patient Registry
by: Masayoshi Harigai, et al.
Published: (2024-07-01)

Penerapan Terapi Masase Kaki Terhadap Penurunan Tingkat Nyeri Lansia Dengan Rheumatoid Arthritis
by: Indah Leviana Putri, et al.
Published: (2024-12-01)

Clinical and Immunological Characteristics of Elderly Onset Rheumatoid Arthritis
by: LI Zhengfang, et al.
Published: (2025-01-01)

Pedobarographic Measurements of Rheumatoid Feet Compared with Clinical Parameters
by: Yasemin YUMUSAKHUYLU, et al.
Published: (2022-03-01)

High-Titer Rheumatoid Factor is Associated with Worse Clinical Outcomes and Higher Needs for Advanced Therapies in Rheumatoid Arthritis Under Real-Life Conditions
by: Victor Davi R. S. Oliveira, et al.
Published: (2024-12-01)

Ultrasonographic evaluation of joint involvement in rheumatoid arthritis: Comparison with conventional radiography and correlation with disease activity parameters
by: Renu Saigal, et al.
Published: (2017-01-01)

Interpretation on the 2024 Chinese Guidelines for the Diagnosis and Treatment of Rheumatoid Arthritis
by: JIANG Nan, et al.
Published: (2024-12-01)

Role of neuroimmunomodulation by vagus nerve stimulation in rheumatoid arthritis: Are we heading towards a drug-free era?
by: Prasan Deep Rath, et al.
Published: (2020-01-01)

Risk Evaluation for the Formation of Gastroduodenal Erosion and Ulceration Induced by Meloxicam in Patients with Seropositive and Seronegative Rheumatoid Arthritis
by: R. A. Pavlyukov, et al.
Published: (2019-05-01)

Impact of Likelihood Ratios of Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide Antibody in Clinical Diagnosis of Rheumatoid Arthritis by Two Available Platforms
by: Juan Irure-Ventura, et al.
Published: (2025-01-01)

Wnt signaling as a translational target in rheumatoid and psoriatic arthritis
by: Gloria Riitano, et al.
Published: (2025-02-01)

The type of infections and the use of antibiotics among patients with rheumatoid arthritis: A review
by: Asma D. Alshammari, et al.
Published: (2025-01-01)

Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review
by: Natasha Cox, et al.
Published: (2025-01-01)

Knowledge on hydroxychloroquine prescription and attitude toward its use in COVID-19 – A survey-based study among doctors
by: T P Afra, et al.
Published: (2021-01-01)

Leprosy—Presenting as Rheumatoid Arthritis Misleading the Correct Diagnosis
by: Dhakal Sagar, et al.
Published: (2025-01-01)

The pro-inflammatory cytokine Tumor Necrosis Factor alpha (TNF-α) in Diabetic Nephropathy
by: Alia KH Mahmoud, et al.
Published: (2024-07-01)

Emodin promotes the recovery of rheumatoid arthritis by regulating the crosstalk between macrophage subsets and synovial fibroblast subsets
by: Lianying Cheng, et al.
Published: (2025-01-01)

Association of vitamin D receptor gene polymorphisms with rheumatoid arthritis
by: Noelia Marquez Pete, et al.
Published: (2021-03-01)

Advanced application of metal nanoparticles in the diagnosis and treatment of rheumatoid arthritis
by: Wenjing Zhang, et al.
Published: (2025-03-01)