Improving vulnerable Calbindin1− neurons in the ventral hippocampus rescues tau-induced impairment of episodic memory

Improving vulnerable Calbindin1− neurons in the ventral hippocampus rescues tau-induced impairment of episodic memory

Abstract Background Intraneuronal accumulation of hyperphosphorylated tau is a hallmark of Alzheimer’s disease (AD). Given the significant correlation between tau pathology and memory loss in AD patients, identifying vulnerable brain regions, particularly susceptible neuron types in these regions, w...

Full description

Saved in:
Bibliographic Details
Main Authors: Huiyang Lei, Jingru Lv, Fuqiang Zhang, Linyu Wei, Kun Shi, Jiale Liu, Ting He, Rui Xiong, Fei Sun, Tongkai Zhong, Jingqi Zhao, Dan Ke, Qun Wang, Peiran Jiang, Ai-Min Bao, Jian-Zhi Wang, Ying Yang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Translational Neurodegeneration
Subjects:
Alzheimer’s disease
Tau
Hippocampus
Episodic memory loss
MARK4
Online Access:https://doi.org/10.1186/s40035-025-00473-w
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items