Improving vulnerable Calbindin1− neurons in the ventral hippocampus rescues tau-induced impairment of episodic memory

Improving vulnerable Calbindin1− neurons in the ventral hippocampus rescues tau-induced impairment of episodic memory

Abstract Background Intraneuronal accumulation of hyperphosphorylated tau is a hallmark of Alzheimer’s disease (AD). Given the significant correlation between tau pathology and memory loss in AD patients, identifying vulnerable brain regions, particularly susceptible neuron types in these regions, w...

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Main Authors: Huiyang Lei, Jingru Lv, Fuqiang Zhang, Linyu Wei, Kun Shi, Jiale Liu, Ting He, Rui Xiong, Fei Sun, Tongkai Zhong, Jingqi Zhao, Dan Ke, Qun Wang, Peiran Jiang, Ai-Min Bao, Jian-Zhi Wang, Ying Yang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Translational Neurodegeneration
Subjects:
Alzheimer’s disease
Tau
Hippocampus
Episodic memory loss
MARK4
Online Access:https://doi.org/10.1186/s40035-025-00473-w
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https://doi.org/10.1186/s40035-025-00473-w

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