Crocin promotes ferroptosis in gastric cancer via the Nrf2/GGTLC2 pathway

Introduction: Gastric cancer (GC) is characterized by high incidence and poor survival rates. Crocin, a natural carotenoid from saffron, exhibits antioxidant, anti-inflammatory, and anti-tumor properties. Ferroptosis, an iron-dependent cell death driven by lipid peroxidation, plays a critical role i...

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Bibliographic Details
Main Authors: Nan Yan, Gaofu Li, Linglin Zhao, Qijing Guo, Jie Yang, Jianhong Liu, Wei Zhou, Yue Gao, Yushuang Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
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Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1527481/full
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