Neuroinflammation causes mitral cell dysfunction and olfactory impairment in a multiple sclerosis model

Neuroinflammation causes mitral cell dysfunction and olfactory impairment in a multiple sclerosis model

Abstract Background Olfactory dysfunction is an underestimated symptom in multiple sclerosis (MS). Here, we examined the pathogenic mechanisms underlying inflammation-induced dysfunction of the olfactory bulb using the animal model of MS, experimental autoimmune encephalomyelitis (EAE). Results Redu...

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Main Authors: Charlotte Schubert, Kristina Schulz, Jana K. Sonner, Alexandros Hadjilaou, Anna-Lena Seemann, Janine Gierke, Vanessa Vieira, Nina Meurs, Marcel S. Woo, Christian Lohr, Fabio Morellini, Daniela Hirnet, Manuel A. Friese
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Neuroinflammation
Subjects:
Multiple sclerosis
Experimental autoimmune encephalomyelitis
Olfactory bulb
Neuroinflammation
Mitral cells
Single-nucleus RNA sequencing
Online Access:https://doi.org/10.1186/s12974-025-03388-5
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https://doi.org/10.1186/s12974-025-03388-5

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