Fibrogenesis-driven tumor progression in clear cell renal cell carcinoma: prognostic, therapeutic implications and the dual role of neuropilin-1

Fibrogenesis-driven tumor progression in clear cell renal cell carcinoma: prognostic, therapeutic implications and the dual role of neuropilin-1

Abstract Background Clear cell renal cell carcinoma (ccRCC) is the predominant subtype of renal cancer, with a poor prognosis driven by therapy resistance and a propensity for recurrence. Tumor microenvironment (TME)-associated fibrosis accelerates disease progression by fostering immune evasion. Ne...

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Bibliographic Details
Main Authors: Kai Wang, Xihao Shen, Jiyue Wu, Qing Bi, Zihao Gao, Zejia Sun, Wei Wang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cancer Cell International
Subjects:
Fibrogenesis
Clear cell renal cell carcinoma
Machine learning
NRP1
Epithelial-to-mesenchymal transition
TGF-β/SMAD pathway
Online Access:https://doi.org/10.1186/s12935-025-03801-2
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https://doi.org/10.1186/s12935-025-03801-2

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