Nitric Oxide‐Releasing Nanoscale Metal‐Organic Layer Overcomes Hypoxia and Reactive Oxygen Species Diffusion Barriers to Enhance Cancer Radiotherapy

Nitric Oxide‐Releasing Nanoscale Metal‐Organic Layer Overcomes Hypoxia and Reactive Oxygen Species Diffusion Barriers to Enhance Cancer Radiotherapy

Abstract Hafnium (Hf)‐based nanoscale metal‐organic layers (MOLs) enhance radiotherapeutic effects of tissue‐penetrating X‐rays via a unique radiotherapy‐radiodynamic therapy (RT‐RDT) process through efficient generation of hydroxy radical (RT) and singlet oxygen (RDT). However, their radiotherapeut...

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Bibliographic Details
Main Authors: Yuxuan Xiong, Jinhong Li, Xiaomin Jiang, Wenyao Zhen, Xin Ma, Wenbin Lin
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Advanced Science
Subjects:
hypoxia
metal‐organic layers
nitric oxide
radiotherapy
reactive oxygen species
Online Access:https://doi.org/10.1002/advs.202413518
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https://doi.org/10.1002/advs.202413518

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