Rhein alleviates hepatic steatosis in NAFLD mice by activating the AMPK/ACC/SREBP1 pathway to enhance lipid metabolism

Rhein alleviates hepatic steatosis in NAFLD mice by activating the AMPK/ACC/SREBP1 pathway to enhance lipid metabolism

Abstract Background Non-alcoholic fatty liver disease (NAFLD) is a common metabolic liver disorder characterized by excessive lipid accumulation. The 5’-adenosine monophosphate-activated protein kinase (AMPK)/acetyl-CoA carboxylase (ACC)/sterol regulatory element-binding protein 1 (SREBP1) pathway p...

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Bibliographic Details
Main Authors: Weiwei Dai, Qishu Hou, Jifeng Ye
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Molecular Medicine
Subjects:
Rhein
Non-alcoholic fatty liver disease
5'-adenosine monophosphate-activated protein kinase signaling pathway
Acetyl-coa carboxylase
Sterol regulatory element-binding protein 1
Online Access:https://doi.org/10.1186/s10020-025-01304-4
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https://doi.org/10.1186/s10020-025-01304-4

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