Long-Term Use of Aldosterone-Receptor Antagonists in Uncontrolled Hypertension: A Retrospective Analysis
Background. The long-term efficacy of aldosterone-receptor antagonists (ARAs) as add-on treatment in uncontrolled hypertension has not yet been reported. Methods. Data from 123 patients (21 with primary aldosteronism, 102 with essential hypertension) with difficult-to-treat hyperten...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.4061/2011/368140 |
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| author | Pieter M. Jansen Koen Verdonk Ben P. Imholz A. H. Jan Danser Anton H. van den Meiracker |
| author_facet | Pieter M. Jansen Koen Verdonk Ben P. Imholz A. H. Jan Danser Anton H. van den Meiracker |
| author_sort | Pieter M. Jansen |
| collection | DOAJ |
| description | Background. The long-term efficacy of aldosterone-receptor antagonists (ARAs) as add-on treatment in uncontrolled hypertension has not yet been reported.
Methods. Data from 123 patients (21 with primary aldosteronism, 102 with essential hypertension) with difficult-to-treat hypertension who received an ARA between May 2005 and September 2009 were analyzed retrospectively for their blood pressure (BP) and biochemical response at first followup after start with ARA and the last follow-up available. Results. Systolic BP decreased by 22±20 and diastolic BP by 9.4±12 mmHg after a median treatment duration of 25 months. In patients that received treatment >5 years, SBP was 33±20 and DBP was 16 ± 13 mmHg lower than at baseline. Multivariate analysis revealed that baseline BP and follow-up duration were positively correlated with BP response. Conclusion. Add-on ARA treatment in difficult-to-treat hypertension results in a profound and sustained BP reduction. |
| format | Article |
| id | doaj-art-c732d733119e48d2b094d08f7c33642c |
| institution | Kabale University |
| issn | 2090-0392 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-c732d733119e48d2b094d08f7c33642c2025-02-03T01:25:36ZengWileyInternational Journal of Hypertension2090-03922011-01-01201110.4061/2011/368140368140Long-Term Use of Aldosterone-Receptor Antagonists in Uncontrolled Hypertension: A Retrospective AnalysisPieter M. Jansen0Koen Verdonk1Ben P. Imholz2A. H. Jan Danser3Anton H. van den Meiracker4Division of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus Medical Center, 3015 CE Rotterdam, The NetherlandsDivision of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus Medical Center, 3015 CE Rotterdam, The NetherlandsDepartment of Internal Medicine, TweeSteden Hospital, 5141 BM Waalwijk, The NetherlandsDivision of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus Medical Center, 3015 CE Rotterdam, The NetherlandsDivision of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus Medical Center, 3015 CE Rotterdam, The NetherlandsBackground. The long-term efficacy of aldosterone-receptor antagonists (ARAs) as add-on treatment in uncontrolled hypertension has not yet been reported. Methods. Data from 123 patients (21 with primary aldosteronism, 102 with essential hypertension) with difficult-to-treat hypertension who received an ARA between May 2005 and September 2009 were analyzed retrospectively for their blood pressure (BP) and biochemical response at first followup after start with ARA and the last follow-up available. Results. Systolic BP decreased by 22±20 and diastolic BP by 9.4±12 mmHg after a median treatment duration of 25 months. In patients that received treatment >5 years, SBP was 33±20 and DBP was 16 ± 13 mmHg lower than at baseline. Multivariate analysis revealed that baseline BP and follow-up duration were positively correlated with BP response. Conclusion. Add-on ARA treatment in difficult-to-treat hypertension results in a profound and sustained BP reduction.http://dx.doi.org/10.4061/2011/368140 |
| spellingShingle | Pieter M. Jansen Koen Verdonk Ben P. Imholz A. H. Jan Danser Anton H. van den Meiracker Long-Term Use of Aldosterone-Receptor Antagonists in Uncontrolled Hypertension: A Retrospective Analysis International Journal of Hypertension |
| title | Long-Term Use of Aldosterone-Receptor Antagonists in Uncontrolled Hypertension: A Retrospective Analysis |
| title_full | Long-Term Use of Aldosterone-Receptor Antagonists in Uncontrolled Hypertension: A Retrospective Analysis |
| title_fullStr | Long-Term Use of Aldosterone-Receptor Antagonists in Uncontrolled Hypertension: A Retrospective Analysis |
| title_full_unstemmed | Long-Term Use of Aldosterone-Receptor Antagonists in Uncontrolled Hypertension: A Retrospective Analysis |
| title_short | Long-Term Use of Aldosterone-Receptor Antagonists in Uncontrolled Hypertension: A Retrospective Analysis |
| title_sort | long term use of aldosterone receptor antagonists in uncontrolled hypertension a retrospective analysis |
| url | http://dx.doi.org/10.4061/2011/368140 |
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