Long-Term Use of Aldosterone-Receptor Antagonists in Uncontrolled Hypertension: A Retrospective Analysis

Background. The long-term efficacy of aldosterone-receptor antagonists (ARAs) as add-on treatment in uncontrolled hypertension has not yet been reported. Methods. Data from 123 patients (21 with primary aldosteronism, 102 with essential hypertension) with difficult-to-treat hyperten...

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Main Authors: Pieter M. Jansen, Koen Verdonk, Ben P. Imholz, A. H. Jan Danser, Anton H. van den Meiracker
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:International Journal of Hypertension
Online Access:http://dx.doi.org/10.4061/2011/368140
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author Pieter M. Jansen
Koen Verdonk
Ben P. Imholz
A. H. Jan Danser
Anton H. van den Meiracker
author_facet Pieter M. Jansen
Koen Verdonk
Ben P. Imholz
A. H. Jan Danser
Anton H. van den Meiracker
author_sort Pieter M. Jansen
collection DOAJ
description Background. The long-term efficacy of aldosterone-receptor antagonists (ARAs) as add-on treatment in uncontrolled hypertension has not yet been reported. Methods. Data from 123 patients (21 with primary aldosteronism, 102 with essential hypertension) with difficult-to-treat hypertension who received an ARA between May 2005 and September 2009 were analyzed retrospectively for their blood pressure (BP) and biochemical response at first followup after start with ARA and the last follow-up available. Results. Systolic BP decreased by 22±20 and diastolic BP by 9.4±12 mmHg after a median treatment duration of 25 months. In patients that received treatment >5 years, SBP was 33±20 and DBP was 16 ± 13 mmHg lower than at baseline. Multivariate analysis revealed that baseline BP and follow-up duration were positively correlated with BP response. Conclusion. Add-on ARA treatment in difficult-to-treat hypertension results in a profound and sustained BP reduction.
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spelling doaj-art-c732d733119e48d2b094d08f7c33642c2025-02-03T01:25:36ZengWileyInternational Journal of Hypertension2090-03922011-01-01201110.4061/2011/368140368140Long-Term Use of Aldosterone-Receptor Antagonists in Uncontrolled Hypertension: A Retrospective AnalysisPieter M. Jansen0Koen Verdonk1Ben P. Imholz2A. H. Jan Danser3Anton H. van den Meiracker4Division of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus Medical Center, 3015 CE Rotterdam, The NetherlandsDivision of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus Medical Center, 3015 CE Rotterdam, The NetherlandsDepartment of Internal Medicine, TweeSteden Hospital, 5141 BM Waalwijk, The NetherlandsDivision of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus Medical Center, 3015 CE Rotterdam, The NetherlandsDivision of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus Medical Center, 3015 CE Rotterdam, The NetherlandsBackground. The long-term efficacy of aldosterone-receptor antagonists (ARAs) as add-on treatment in uncontrolled hypertension has not yet been reported. Methods. Data from 123 patients (21 with primary aldosteronism, 102 with essential hypertension) with difficult-to-treat hypertension who received an ARA between May 2005 and September 2009 were analyzed retrospectively for their blood pressure (BP) and biochemical response at first followup after start with ARA and the last follow-up available. Results. Systolic BP decreased by 22±20 and diastolic BP by 9.4±12 mmHg after a median treatment duration of 25 months. In patients that received treatment >5 years, SBP was 33±20 and DBP was 16 ± 13 mmHg lower than at baseline. Multivariate analysis revealed that baseline BP and follow-up duration were positively correlated with BP response. Conclusion. Add-on ARA treatment in difficult-to-treat hypertension results in a profound and sustained BP reduction.http://dx.doi.org/10.4061/2011/368140
spellingShingle Pieter M. Jansen
Koen Verdonk
Ben P. Imholz
A. H. Jan Danser
Anton H. van den Meiracker
Long-Term Use of Aldosterone-Receptor Antagonists in Uncontrolled Hypertension: A Retrospective Analysis
International Journal of Hypertension
title Long-Term Use of Aldosterone-Receptor Antagonists in Uncontrolled Hypertension: A Retrospective Analysis
title_full Long-Term Use of Aldosterone-Receptor Antagonists in Uncontrolled Hypertension: A Retrospective Analysis
title_fullStr Long-Term Use of Aldosterone-Receptor Antagonists in Uncontrolled Hypertension: A Retrospective Analysis
title_full_unstemmed Long-Term Use of Aldosterone-Receptor Antagonists in Uncontrolled Hypertension: A Retrospective Analysis
title_short Long-Term Use of Aldosterone-Receptor Antagonists in Uncontrolled Hypertension: A Retrospective Analysis
title_sort long term use of aldosterone receptor antagonists in uncontrolled hypertension a retrospective analysis
url http://dx.doi.org/10.4061/2011/368140
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