Contrastive sequence signatures between the both sides of a recombination spot reveal an adaptation at PPARD locus from standing variation for pleiotropy since out-of-Africa dispersal

Contrastive sequence signatures between the both sides of a recombination spot reveal an adaptation at PPARD locus from standing variation for pleiotropy since out-of-Africa dispersal

Abstract Background Drug metabolism and transporter genes are a specialized class of genes involved in absorption, distribution, metabolism and excretion. They easily present distinct genetic population differentiation and are vulnerable to natural selection. Results We initiated a study using a spe...

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Bibliographic Details
Main Authors: Weihua Shou, Chenhui Zhang, Ying Wang, Haifeng Wang, Lei Guo, Li Li, Tiesong Zhang, Wei Huang, Jinxiu Shi
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Genomics
Subjects:
Drug gene
Genetic stratification
Positive selection
Evolutionary history
Selective pressure
Causal prioritization
Online Access:https://doi.org/10.1186/s12864-025-11620-y
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https://doi.org/10.1186/s12864-025-11620-y

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