A novel self-assembling peptide nanofiber hydrogel with glucagon-like peptide-1 functionality enhances islet survival to improve islet transplantation outcome in diabetes treatment

A novel self-assembling peptide nanofiber hydrogel with glucagon-like peptide-1 functionality enhances islet survival to improve islet transplantation outcome in diabetes treatment

Abstract Islet transplantation is a promising therapy for diabetes, yet the limited survival and functionality of transplanted islet grafts hinder optimal outcomes. Glucagon-like peptide-1 (GLP-1), an endogenous hormone, has shown potential to enhance islet survival and function; however, its system...

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Main Authors: Xiangheng Cai, Mengnan Zhang, Jiaqi Zou, Le Wang, Yixiang Zhan, Dandan Li, Tingsheng Jiang, Nijat Alim, Zhaoce Liu, Jiuxia Yang, Na Liu, Tengli Liu, Peng Sun, Xuejie Ding, Boya Zhang, Zewen Liu, Xuelian Wang, Rui Liang, Jinzhen Cai, Jie Gao, Jinglin Cao, Shusen Wang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Nanobiotechnology
Subjects:
Supramolecular hydrogel
Peptide nanofiber
Self-assembly
Islet transplantation
Diabetes
Online Access:https://doi.org/10.1186/s12951-024-03072-5
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https://doi.org/10.1186/s12951-024-03072-5

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