Susceptibility to and severity of tuberculosis infection in mice depends upon MHC-II-determined level of activation-inhibition balance in CD4 T-cells

Susceptibility to and severity of tuberculosis infection in mice depends upon MHC-II-determined level of activation-inhibition balance in CD4 T-cells

Previously we have shown that H2-congenic recombinant mice of the B6.I-9.3 (H2-Ab1j) strain are significantly more susceptible to tuberculosis (TB) infection compared to their C57BL/6 (B6, H2-Ab) ancestors. Impaired TB control was characterized by decreased selection and maintenance of CD4+ T-cells,...

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Bibliographic Details
Main Authors: Nadezhda Logunova, Marina Kapina, Valeriia Kriukova, Olga Britanova, Konstantin Majorov, Irina Linge, Alexander Apt
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
MHC-II alleles
tuberculosis
CD4 T-cell populations
immune activation/exhaustion
IFN-γ
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1608769/full
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