Susceptibility to and severity of tuberculosis infection in mice depends upon MHC-II-determined level of activation-inhibition balance in CD4 T-cells
Previously we have shown that H2-congenic recombinant mice of the B6.I-9.3 (H2-Ab1j) strain are significantly more susceptible to tuberculosis (TB) infection compared to their C57BL/6 (B6, H2-Ab) ancestors. Impaired TB control was characterized by decreased selection and maintenance of CD4+ T-cells,...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-08-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1608769/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|