Identification of druggable binding sites and small molecules as modulators of TMC1

Identification of druggable binding sites and small molecules as modulators of TMC1

Abstract Our ability to hear and maintain balance relies on the proper functioning of inner ear sensory hair cells, which translate mechanical stimuli into electrical signals via mechano-electrical transducer (MET) channels, composed of TMC1/2 proteins. However, the therapeutic use of ototoxic drugs...

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Main Authors: Pedro De-la-Torre, Claudia Martínez-García, Paul Gratias, Matthew Mun, Paula Santana, Nurunisa Akyuz, Wendy González, Artur A. Indzhykulian, David Ramírez
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07943-x
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https://doi.org/10.1038/s42003-025-07943-x

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