Dual RNA-seq analysis reveals the interaction between multidrug-resistant Klebsiella pneumoniae and host in a mouse model of pneumonia

Dual RNA-seq analysis reveals the interaction between multidrug-resistant Klebsiella pneumoniae and host in a mouse model of pneumonia

Abstract Background Multidrug-resistant Klebsiella pneumoniae (MDR-KP) poses a significant global health threat, associated with high morbidity and mortality rates among hospitalized patients. The interaction between MDR-KP and its host is highly complex, and few studies have investigated these inte...

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Bibliographic Details
Main Authors: Xiaolin Song, Chengyu Sui, Meng Lv, Cuicui Jiang, Lingfei Hu, Yongqiang Jiang, Dongsheng Zhou, Wenhui Yang, Chenxi Dai
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Microbiology
Subjects:
Multidrug-resistant Klebsiella pneumoniae
Dual RNA-seq analysis
Aerosolized intratracheal inoculation
Hypoxia
Siderophores
Online Access:https://doi.org/10.1186/s12866-025-04044-x
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https://doi.org/10.1186/s12866-025-04044-x

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