Enhancement of doxorubicin efficacy by diosmetin through DNA damage accumulation and P-glycoprotein inhibition in breast cancer cells

Enhancement of doxorubicin efficacy by diosmetin through DNA damage accumulation and P-glycoprotein inhibition in breast cancer cells

Abstract Doxorubicin (DOX) is widely used in treatment; however, its efficacy is often compromised by multidrug resistance (MDR), limiting therapeutic outcomes. This study investigates the anticancer potential of diosmetin (DT), a metabolite of diosmin commonly used in chronic venous insufficiency,...

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Bibliographic Details
Main Authors: Monika Michalczyk, Ewelina Humeniuk, Joanna Kubik, Grzegorz Adamczuk, Mariola Michalczuk, Barbara Madej-Czerwonka, Maciej Czerwonka, Agnieszka Korga-Plewko
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Diosmetin
Diosmin
Doxorubicin
DNA damage
ABCB1 activity
Online Access:https://doi.org/10.1038/s41598-025-16681-3
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https://doi.org/10.1038/s41598-025-16681-3

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