Tissue extracellular vesicles suppress neonatal cardiac regeneration: a Pak2-Erk1/2-mediated macrophage paracrine signaling

Tissue extracellular vesicles suppress neonatal cardiac regeneration: a Pak2-Erk1/2-mediated macrophage paracrine signaling

Myocardial infarction leads to cardiomyocyte loss, and the compromised proliferative capacity of cardiomyocytes after birth hinders the process of heart repair, ultimately culminating in heart failure. Extracellular vesicles (EVs), known as cell-secreted “messengers”, play a pivotal role in tissue p...

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Bibliographic Details
Main Authors: Li Yongwei, Zhang Laihai, Wu Yating, Wei Lu, Zhang Zhenchun, Mo Hanling, Liu Zhongmin, Wang Xianyun, Shen Yunli, Zhu Hongming
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2025-02-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
myocardial infarction (MI)
extracellular vesicle (EV)
cell proliferation
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2024193
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https://www.sciengine.com/doi/10.3724/abbs.2024193

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